The Australian-led clinical trial ENZAMET has shown that the addition of hormone therapy with a medicine called enzalutamide to standard therapy (ADT alone to ADT plus docetaxel) can improve overall survival for people with advanced, hormone-sensitive prostate cancer.
In June 2019, the Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP) presented the interim results from the ENZAMET study in the Plenary Session at the American Society of Clinical Oncology (ASCO) Annual Meeting.
Today, at the ASCO 2022 Annual Meeting in Chicago, ANZUP presented the planned analysis results of the ENZAMET study, after patients had been followed on average for more than 5 years.
ENZAMET showed that people with this sort of cancer who receive enzalutamide added to standard treatment are 30% less likely to die compared to people receiving standard treatment alone.
People with metastatic hormone sensitive prostate cancer (mHSPC) received enzalutamide or non-steroidal anti-androgen therapy (NSAA: bicalutamide, nilutamide, or flutamide) in addition to standard of care therapy (androgen deprivation therapy, ADT), with or without docetaxel chemotherapy. This translated into 67% chance of being alive at the 5-year mark with enzalutamide compared to a 57% chance for people receiving standard treatment plus non-steroidal anti-androgen therapy.
Study Co-Chair and Board Chair of ANZUP, Professor Ian Davis, said, “ENZAMET is a unique collaboration of clinicians and scientists from Australia, New Zealand, Ireland, UK, Canada, and the USA, all coming together to work with the community to find better ways of treating prostate cancer. ENZAMET won the 2020 Trial of the Year Award, as well as awards for community involvement, and for high quality statistical conduct. Now we have very mature results confirming that the benefit of enzalutamide treatment persists even after much longer follow-up, and we continue to see other informative results emerging from this very important trial.”
“Although ENZAMET was not primarily designed to assess the impact of testosterone suppression plus enzalutamide plus docetaxel (ie potent hormonal-chemotherapy) over testosterone suppression plus enzalutamide (potent hormonal therapy without chemotherapy), the data would suggest that the addition of concurrent docetaxel to potent hormonal therapy may only benefit people who are fit for docetaxel and have the poorest prognosis disease (ie presentation of a higher volume of metastatic disease as first diagnosis of prostate cancer). For all other patients, such as those not fit for docetaxel or not likely to benefit from docetaxel, potent hormonal therapy with testosterone suppression plus enzalutamide is one of the life prolonging treatment plans we should be discussing with all of our patients who are starting hormonal therapy for metastatic disease,” said Study Co-Chair Professor Christopher Sweeney.
Furthermore, Professor Sweeney, Medical Oncologist at the Dana-Farber Cancer Institute, noted, “ENZAMET had the flexibility to allow physicians and patients to decide whether concurrent docetaxel was an appropriate option for each unique patient and this has helped provide insights as to which patients benefit from which combination therapy. This was only possible because of the patients’ and research teams’ commitment to the clinical research process”.
The side effects of addition of enzalutamide to standard of care were overall similar to what has been experienced with enzalutamide in previous clinical trials.
- Uro Today: Ian Davis joins Alicia Morgans to discuss overall survival outcomes in ENZAMET (ANZUP 1304)
- JCO, Vol 40, Issue 19 2022: Stockler-2022-Reply-to-l-marandino-et-al
- ENZAMET ASCO 2022 Presentation
- ANZUP ENZAMET ASCO 2022 Media Release FINAL 23 May 2022
- Updated results from the ENZAMET clinical trial show a clinically meaningful survival benefit from novel hormone therapy for people with metastatic hormone sensitive prostate cancer
- View the slides from the ASCO Plenary presentation here
- Watch the ENZAMET trial results feature on Channel Nine news
- Read the ANZUP ENZAMET press release
- More about ENZAMET & Health Related Quality of Life (HRQoL) results
- ANZUP’s ENZAMET trial results recognised as one of the most important clinical research advances of the past year
- Enzalutamide receives U.S. FDA approval for treatment of men with metastatic hormone-sensitive prostate cancer
- Read the 2019 NEJM article – Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer
- Watch the ASCO Plenary session with Prof. Chris Sweeney presenting the ENZAMET trial results
- Watch a discussion about the academic collaboration of the ENZAMET trial
- Watch The ASCO Post interview with Prof. Chris Sweeney and Prof. Ian Davis talking about ANZUP
The ASCO Post with Alicia Morgans and Ian Davis – https://ascopost.com/videos/2022-asco-annual-meeting/alicia-morgans-and-ian-davis-on-prostate-cancer-updated-overall-survival-outcomes-with-enzalutamide/
Uromigos podcast with Ian Davis – https://anchor.fm/the-uromigos/episodes/Episode-177-ENZAMET-at-ASCO-2022-e1jhmo1
UroToday – https://www.urotoday.com/conference-highlights/asco-2022/asco-2022-prostate-cancer/137644-asco-2022-updated-overall-survival-outcomes-in-enzamet-anzup-1304-an-international-cooperative-group-trial-of-enzalutamide-in-mhspc.html?mtm_campaign=Davis_SocialASCO22_ID137644
ASCO Daily News – https://dailynews.ascopubs.org/do/10.1200/ADN.22.201027/full/
UroToday – Karim Fizazi and Alicia Morgans discuss the latest ENZAMET updates shared at ASCO 2022