Prostate — Recruiting

Cancer is a disease that changes over time. When cancer changes, a treatment that worked before might start to become less effective. Hormone tablets are approved in Australia to treat advanced prostate cancer, however, even if these drugs are helpful their effectiveness usually diminishes over time. The ANZadapt trial is testing a new idea to try to slow down the changes in cancer by giving treatment for just long enough to control the cancer, and then pausing the treatment if the cancer is controlled. If the cancer starts to grow again, the treatment is started again to try to control the cancer again. This idea is called ‘adaptive therapy’ as the treatment is adapted for each person. Adaptive therapy may slow how cancer changes and keep treatment useful for as long as possible when a treatment can control a cancer, but can't cure the cancer. The ANZadapt aims to find out if this pause/restart strategy is better than taking hormone tablets every day continuously.
If you think this trial might be right for you, please ask your doctor.
If you think this trial might be right for you, please ask your doctor.
Trial Title
Phase II randomised controlled trial of patient-specific adaptive versus continuous Abiraterone or eNZalutamide in metastatic castration-resistant prostate cancer
Cancer Type
Trial Status
Protocol Number
ANZUP 2101
Co-ordinating centre
Study Chair
Craig Gedye
Patient Population
Patients with asymptomatic or minimally symptomatic metastatic CRPC in whom treatment with AA or ENZ is indicated.
Recruitment Target
84 patients in Australia and New Zealand
The ANZadapt Trial is an investigator-initiated trial sponsored and led by ANZUP. This trial has received funding from a philanthropic grant awarded by the Anticancer Fund (ACF) in Belgium. This trial is a collaboration between ANZUP, the Hunter Medical Research Institute (HMRI) Clinical Trials Unit and the Leiden University Medical Center (LUMC)
Detailed Information
Participating Centres
Calvary Mater Newcastle
GenesisCare Northern Cancer Institute St Leonard's
Border Medical Oncology Research Unit
Chris O'Brien Lifehouse - Sydney Local Health District
Sydney Adventist Hospital

Box Hill Hospital - Eastern Health

Mater Cancer Care Centre, Mater Misericordiae Ltd
Sunshine Coast University Hospital

Royal Adelaide Hospital - Central Adelaide Local Health Network Inc.
Icon Cancer Centre Adelaide - Kurrulta Park

Fiona Stanley Hospital