ANZUP Co-operative multi-centre cystectomy database & ACCEPT-U

The Urological Society of Australia and New Zealand (USANZ) has expressed interest in seeking funding for national cystectomy database and are seeking collaboration from other groups already involved in this data collection.

The ACCEPT database has 548 cystectomy cases currently. ANZUP will continue with the project and encourage more sites to join while the USANZ project is in development.

Exciting progress has been made with HREC approval for the ACCEPT-U database. A guideline for sites to join ACCEPT/ACCEPT-U has been developed.

Furthermore, a combined retrospective analysis of nephroureterectomies from the ACCEPT-U database is being written up for publication. Some of these data were presented at the USANZ meeting.

Utilising a pro‐inflammatory gene signature and immune cell markers to identify non‐muscle invasive bladder cancer patients at high risk of intravesical BCG failure

As of February 29, 2024, Monash Pathology has prepared 16 out of 50 samples (from 25 patients pre- and post-treatment) for staining and sequencing. Our goal is to compile this data for presentation at the ANZUP Annual Scientific Meeting (ASM) in July 2024 and a European meeting later this year.

The MBC Trial ‐ Assessment of the diagnostic utility of multi‐parametric MRI Before cystoscopy in patients presenting with a bladder mass: a multicentre prospective study

As of 31 March, we’ve successfully recruited 61 out of 100 patients for the study. VIRADS 4/5 is strongly predictive as a cut-off for T2 disease. Additionally, the kurtosis value shows a correlation with tumour grade and serves as a predictive marker for muscle invasive disease. To extend the study to other sites, we’ll need both funding and buy-in from site radiologists.