Pain-Free TRUS B

 Prostate — Closed

Pain-Free TRUS B
A prostate biopsy involves taking small pieces of the prostate through a needle so that it can be looked at with a microscope. A TransRectal UltraSound (TRUS) guided biopsy is the usual way of performing a biopsy and involves inserting a thin needle through the wall of the rectum into the prostate using the guidance of an ultrasound probe. An injection of a local anaesthetic (lignocaine) around the prostate is the standard way of reducing the discomfort of a prostate biopsy. Methoxyflurane (Penthrox®) is a drug given with a simple inhaler and is widely used by first aid services to reduce pain. This randomised trial will determine if the discomfort of prostate biopsies can be reduced by giving people inhaled methoxyflurane in addition to their standard injections of local anaesthetic. This study will include 420 people and is being conducted by ANZUP Cancer Trials Group in collaboration with the NHMRC Clinical Trials Centre, University of Sydney.
If you think this trial might be right for you, please ask your doctor.
Trial Title
A phase 3 double-blind placebo-controlled randomized trial of methoxyflurane with periprostatic local anaesthesia to reduce the discomfort of transrectal ultrasound-guided prostate biopsy
Cancer Type
Prostate
Trial Status
Closed
Protocol Number
ANZUP 1501
Trial Email
trusb.study@sydney.edu.au
Co-ordinating centre
Study Chair
Dr Nicholas Buchan
Patient Population
Men scheduled to undergo their first TRUS biopsy of the prostate for a raised PSA or abnormal digital rectal examination (DRE).
Recruitment Target
420 participants
Acknowledgements
We acknowledge MDI for the provision of Penthrox®.
Detailed Information
ANZCTR
Further Information
ClinicalTrials.gov
Participating Centres