P3BEP

 Testicular — Recruiting

Phase III Accelerated BEP Trial
The current gold standard practice for the treatment of germ cell tumours is the use of a chemotherapy combination called BEP which consists of three chemotherapy agents, Bleomycin, Etoposide and Cisplatin administered on a 3 weekly cycle. BEP is given with a drug called pegylated G-CSF (or pegfilgrastim) which stimulates white blood cell production. The purpose of this study is to determine whether giving the same dose of BEP on a 2-weekly schedule will be more effective than a 3-weekly schedule and will be well tolerated. The 2-weekly schedule is called ‘accelerated BEP’.
If you think this trial might be right for you, please ask your doctor.
If you think this trial might be right for you, please ask your doctor.
Trial Title
Accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours: a randomised phase III trial
Cancer Type
Testicular
Trial Status
Recruiting
Protocol Number
ANZUP 1302
Co-ordinating centre
Study Chair
Assoc/Prof Peter Grimison
Patient Population
Patients aged 11 to 45 years with intermediate or poor-risk advanced germ cell tumours requiring first-line chemotherapy
Recruitment Target
Stage 1: 150 patients Stage 2: 350 patients
Acknowledgements
This investigator-initiated study is being led by ANZUP in collaboration with the NHMRC Clinical Trials, the Children’s Oncology Group, Cambridge Clinical Trials Centre and the Australian and New Zealand Children’s Haematology/Oncology Group (ANZCHOG). ANZUP receives valuable infrastructure support from the Australian Government through Cancer Australia. Special thanks also to the Clinical Trials Awards and Advisory Committee (UK) and National Cancer Institute (USA) for funding this study.
Detailed Information
Further Information
ClinicalTrials.gov
Participating Centres
NSW
Calvary Mater Newcastle
Chris O'Brien Lifehouse - Sydney Local Health District
Concord Repatriation General Hospital
Macquarie University Hospital
Nepean Hospital
The Tweed Hospital
Prince of Wales Hospital - South Eastern Sydney Health District
Royal North Shore Hospital - Northern Sydney Local Health District
Sydney Adventist Hospital
Border Medical Oncology Research Unit

VIC
Austin Health
Eastern Health
Peter MacCallum Cancer Centre

QLD
Princess Alexandra Hospital
Queensland Children's Hospital
Royal Brisbane & Women's Hospital

SA
Flinders Medical Centre
Royal Adelaide Hospital - Central Adelaide Local Health Network Inc.

TAS
Royal Hobart Hospital

WA
Fiona Stanley Hospital

NZ
Auckland City Hospital
Christchurch Hospital
Palmerston North Hospital
Starship Children's Hospital
Christchurch Children's Haematology Hospital

UK
Royal Preston Hospital
Beatson West of Scotland Cancer Centre
Bristol University Hospital
Velindre Cancer Centre
Cambridge University Hospital Paediatric
University Hospital Southampton
The Royal Marsden Hospital
St James Hospital
Barts Health NHS Trust, Bartholomew's Hospital
Nottingham University Hospitals NHS Trust - City Hospital Campus
Belfast City Hospital
Derriford Hospital, Plymouth
Northern General Hospital - Sheffield
Aberdeen Royal Infirmary
University College London Hospitals

USA
Washington University School of Medicine
Rady Children’s Hospital
Augusta University Medical Centre
Vanderbilt University Medical Centre
Lucile Packard Children's Hospital Stanford
Memorial Health University Medical Centre
University of Mississippi Medical Centre
Geisinger Medical Center
Palmetto Health Richland
Methodist Children’s Hospital of South Texas
University of Wisconsin Hospital
East Tennessee Children's Hospital
Miller Children's and Women's Hospital Long Beach
Roswell Park Cancer Center
USC / Norris Comprehensive Cancer Care
Broward HealthCare
Dana-Farber Cancer Institute
UT Southwestern Simmons Cancer Center
The Lundquist Institute
Dayton Children’s Hospital
University of Texas Science Center at San Antonio
Mayo Clinic
Advocate Children’s Hospital – Oak Lawn
Carolinas Medical Center
Memorial Sloan Kettering Cancer Center
Loma Linda University Medical Center
University of Iowa - Holden Comprehensive Cancer Center
Presbyterian Hospital New Mexico
St Mary's Hospital - Florida
Hackensack University Medical Center
Providence Sacred Heart Medical Center and Children's Hospital
Dell Children’s Medical Center

Participating Centres