ENZAMET

 Prostate — In Follow-up

ENZAMET
Enzalutamide is a new hormone treatment taken as tablets. Previous trials have proven that enzalutamide improves survival and quality of life in men with prostate cancer that has stopped responding to standard hormone treatments and chemotherapy. This large, international randomised trial will determine if treatment with enzalutamide can improve survival and quality of life in men starting hormone treatment for newly diagnosed prostate cancer that has spread beyond the prostate. The trial is being led from Australia by ANZUP in collaboration with the NHMRC Clinical Trials Centre. It involved 1,125 men from Australia, New Zealand, Canada, the US, Ireland, and the UK. In June 2019 ANZUP reported that the ENZAMET clinical trial met its primary endpoint of improved survival at the planned first interim analysis. Men with metastatic hormone sensitive prostate cancer (mHSPC) received enzalutamide or non-steroidal anti-androgen therapy (NSAA: bicalutamide, nilutamide, or flutamide) in addition to standard of care therapy (androgen deprivation therapy, ADT), with or without docetaxel chemotherapy. The ENZAMET trial showed a 33% improvement in overall survival and a 60% improvement in progression-free survival, for men who received enzalutamide. This translated into 80% chance of survival at 3 years with enzalutamide versus 72% with NSAA.
If you think this trial might be right for you, please ask your doctor.
If you think this trial might be right for you, please ask your doctor.
Trial Title
Enzalutamide in first line androgen deprivation therapy for metastatic prostate cancer: a randomised phase III trial
Cancer Type
Prostate
Trial Status
In Follow-up
Protocol Number
ANZUP 1304
Co-ordinating centre
Study Chair
Professor Ian Davis and Professor Christopher Sweeney
Patient Population
Men with metastatic prostate cancer commencing androgen deprivation therapy
Detailed Information
Further Information
ClinicalTrials.gov
Participating Centres
NSW
Central West Cancer Services
Chris O'Brien Lifehouse - Sydney Local Health District
Concord Repatriation General Hospital
Nepean Hospital
North Coast Cancer Institute, Coffs Harbour
GenesisCare Northern Cancer Institute St Leonard's
Mid North Coast Local Health District - Port Macquarie Base Hospital
Prince of Wales Hospital - South Eastern Sydney Health District
Riverina Cancer Care Centre
St George Hospital - South Eastern Sydney Local Health District (SESLHD)
St Vincent's Hospital - Sydney
Sydney Adventist Hospital
North West Cancer Centre -Tamworth Hospital
The Tweed Hospital
Wollongong Hospital
Border Medical Oncology Research Unit

VIC
Austin Hospital
Australian Urology Associates
Bendigo Hospital
Eastern Health
Geelong Hospital
Goulburn Valley Health
Monash Cancer Center - Moorabbin
Peninsula South Eastern Haematology & Oncology Group (PSEHOG)
Peter MacCallum Cancer Centre - East Melbourne
St Vincent's Hospital - Melbourne

QLD
Gold Coast Hospital
Nambour General Hospital
Princess Alexandra Hospital
Royal Brisbane & Women's Hospital
The Townsville Hospital

NT
Royal Darwin Hospital

SA
Ashford Cancer Centre Research
Flinders Medical Centre
Royal Adelaide Hospital - Central Adelaide Local Health Network Inc.

TAS
Royal Hobart Hospital

WA
Fiona Stanley Hospital
Sir Charles Gairdner Hospital 

NZ
Auckland City Hospital
Christchurch Hospital
Waikato General Hospital

UK
St James Hospital
Aberdeen Royal Infirmary
Royal Sussex Hospital
Great Western General Hospital
Guy's and St. Thomas Hospital
Kent & Canterbury Hospital
Royal Cornwall Hospital
Barts Health NHS Trust, Bartholomew's Hospital
The Royal Marsden Hospital
University Hospital Southampton
University College London Hospitals
Velindre Cancer Centre

Ireland
Adelaide and Meath Hospital – National Children Hospital
Beacon Private Hospital Dublin
Beaumont Hospital
Galway University Hospital
Mater Misericordiae University Hospital
Mater Private Hospital
St Vincents University Hospital
University Hospital Waterford

Canada
Algoma District Cancer Program Sault Area Hospital
Allan Blair Cancer Centre
BC Cancer Agency (BCCA) Fraser Valley
BC Cancer Agency Vancouver Cancer Centre
Cambridge Memorial Hospital
Cancer Centre of Southeastern Ontario at Kingston General Hospital
Cancer Care Manitoba
Hopital Notre-Dame
CHUQ-Pavillon Hotel-Dieu de Quebec
Cross Cancer Institute
Dr. Everett Chalmers Hospital - Horizon Health Network
Juravinski Cancer Centre
Lakeridge Health Oshawa
London Regional Cancer Program
Ottawa Hospital Cancer Centre
Princess Margaret Cancer Centre
QEII Health Sciences Centre CDHA
Saint John Regional Hospital
Saskatoon Cancer Centre
Southern Alberta Institute of Urology
Thunder Bay Regional Health Science Centre

USA
Dana-Farber Cancer Institute

Participating Centres